Vodobatinib (SCO-088, SUN-K706; K-0706)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $745 | Check With Us |
| 200mg | $1115 | Check With Us |
| 1g | $1875 | Check With Us |
: Cat #: V41836 CAS #: 1388803-90-4 Purity ≥ 99%
Description: Vodobatinib (SCO-088, SUN-K706; K-0706) is a novel third generation BCR-ABL1 tyrosine kinase inhibitor/TKI with anticancer activity.
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| Molecular Weight (MW) | 453.926 |
|---|---|
| Molecular Formula | C27H20ClN3O2 |
| CAS No. | 1388803-90-4 |
| SMILES Code | CC1=C(C=C(C(NNC(C2=C(Cl)C=CC=C2C)=O)=O)C=C1)C#CC(C=N3)=CC4=C3C=CC=C4 |
| Synonyms | K0706; K-0706; K0706; Vodobatinib |
| Protocol | In Vitro | In Ba/F3 cells expressing BCR-ABL1, BCR-ABL1L248V, BCR-ABL1Y253H, or BCR-ABL1E255V, Vodobatinib (K0706; 0-2000 nM) treatment shows potent inhibition of BCR-ABL1 tyrosine autophosphorylation. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2030 mL | 11.0150 mL | 22.0300 mL | 44.0600 mL |
| 5mM | 0.4406 mL | 2.2030 mL | 4.4060 mL | 8.8120 mL |
| 10mM | 0.2203 mL | 1.1015 mL | 2.2030 mL | 4.4060 mL |
| 20mM | 0.1102 mL | 0.5508 mL | 1.1015 mL | 2.2030 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.