Verapamil HCl (CP-16533-1)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
25g	$420	Check With Us
50g	$700	Check With Us
100g	$1050	Check With Us

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Cat #: V0369 CAS #: 152-11-4 (HCl) Purity ≥ 98%

Description: Verapamil (sold under various trade names such as: Calan, Cordilox, Dexverapamil, Falicard, Finoptin, Hydrochloride, Verapamil, Iproveratril, Isoptin, Isoptine, Izoptin, Lekoptin) is a selective and potent L-type calcium channel blocker in the phenylalkylamine class, it is an FDA approved medication used for the treatment of high blood pressure, angina (chest pain from not enough blood flow to the heart), and supraventricular tachycardia.

References: Rehnqvist N,et al. Effects of metoprolol vs verapamil in patients with stable angina pectoris. The Angina Prognosis Study in Stockholm (APSIS). Eur Heart J. 1996 Jan;17(1):76-81.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	491.06
Molecular Formula	C27H38N2O4.HCl
CAS No.	152-11-4 (HCl)
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 98 mg/mL (199.6 mM)r
	Water: 50 mg/mL (101.8 mM)r
	Ethanol: 12 mg/mL (24.4 mM)
Synonyms	CP-16533-1; Lekoptin; Izoptin; CP16533-1; CP 16533-1; (±)-Verapamil hydrochloride; Isoptine, Isoptin, Verapamil HCl, Verapamil, Calan, Cordilox, Dexverapamil, Falicard, Finoptin, Hydrochloride, Iproveratril,

Protocol	In Vitro	The EverFluor FL Verapamil (EFV) uptake by TR-iBRB2 cells is inhibited by cationic drugs, and inhibits by verapamil in a concentration-dependent manner with an IC50 of 98.0 μM

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0364 mL	10.1821 mL	20.3641 mL	40.7282 mL
5mM	0.4073 mL	2.0364 mL	4.0728 mL	8.1456 mL
10mM	0.2036 mL	1.0182 mL	2.0364 mL	4.0728 mL
20mM	0.1018 mL	0.5091 mL	1.0182 mL	2.0364 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.