Vatalanib (PTK-787; ZK222584; CGP79787) 2HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $650 | Check With Us |
| 1g | $900 | Check With Us |
| 5g | $2280 | Check With Us |
: Cat #: V0515 CAS #: 212141-51-0 Purity ≥ 98%
Description: Vatalanib (PTK787 or ZK-222584, cpg-79787 2HCl) 2HCl is a novel, potent and orally bioavailable inhibitor of VEGFR2/KDR with potential anticancer activity.
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| Molecular Weight (MW) | 419.73 |
|---|---|
| Molecular Formula | C20H15ClN4.2HCl |
| CAS No. | 212141-51-0 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 85 mg/mL (202.5 mM)r |
| Water: 10 mg/mL (23.8 mM)r | |
| Ethanol: 6 mg/mL (14.3 mM) | |
| SMILES Code | ClC1=CC=C(NC2=NN=C(CC3=CC=NC=C3)C4=C2C=CC=C4)C=C1.[H]Cl.[H]Cl |
| Synonyms | ZK 222584 (cpg-79787) 2HCl; ZK 222584; ZK222584; ZK-222584; PTK787; PTK 787; CGP 79787; CGP-797870; ZK-232934; PTK-787; ZK 232934; ZK232934; CGP79787D; PTK787/ZK 222584; CGP-7978. |
| Protocol | In Vitro | Vatalanib also inhibits Flk, c-Kit and PDGFRβ with IC50 of 270 nM, 730 nM and 580 nM, respectively. Vatalanib shows the anti-proliferation effect by inhibiting thymidine incorporation induced by VEGF in HUVECs with and IC50 of 7.1 nM, and dose-dependently suppresses VEGF-induced survival and migration of endothelial cells in the same dose range without cytotoxic or antiproliferative effect on cells that do not express VEGF receptors. |
|---|---|---|
| In Vivo | Vatalanib induces dose-dependent inhibition of the angiogenic response to VEGF and PDGF in both a growth factor implant model and a tumor cell-driven angiogenesis model after once-daily oral dosing (25-100 mg/kg). In the same dose range, Vatalanib also inhibits the growth and metastasesof several human carcinomas in nude mice without significant effect on circulating blood cells or bone marrow leukocytes. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3825 mL | 11.9124 mL | 23.8248 mL | 47.6497 mL |
| 5mM | 0.4765 mL | 2.3825 mL | 4.7650 mL | 9.5299 mL |
| 10mM | 0.2382 mL | 1.1912 mL | 2.3825 mL | 4.7650 mL |
| 20mM | 0.1191 mL | 0.5956 mL | 1.1912 mL | 2.3825 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.