Vanoxerine dihydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $650 | Check With Us |
| 500mg | $1100 | Check With Us |
| 1g | $1650 | Check With Us |
: Cat #: V27943 CAS #: 67469-78-7 Purity ≥ 99%
Description: Vanoxerine dihydrochloride (GBR-12909; I-893) is a novel, potent, competitive and highly selective dopamine ruptake inhibitor (Ki=1 nM) with the potential for the treatment of atrial fibrillation.
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- Physicochemical and Storage Information
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- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 523.4898 |
|---|---|
| Molecular Formula | C28H34Cl2F2N2O |
| CAS No. | 67469-78-7 |
| Protocol | In Vitro | Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT |
|---|---|---|
| In Vivo | Vanoxerine dihydrochloride (GBR-12909 dihydrochloride) inhibits the uptake of dopamlne (DA), with an IC50 in the low nanomolar range, and is several-fold less potent as inhibitors of the uptake of noradrenaline and 5-HT | |
| Animal model | Male mice (ddY strain at 6 weeks of age） | |
| Dosages | 2.5, 5, 10, 20 mg/kg | |
| Administration | Intraperitoneal injection |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9103 mL | 9.5513 mL | 19.1026 mL | 38.2051 mL |
| 5mM | 0.3821 mL | 1.9103 mL | 3.8205 mL | 7.6410 mL |
| 10mM | 0.1910 mL | 0.9551 mL | 1.9103 mL | 3.8205 mL |
| 20mM | 0.0955 mL | 0.4776 mL | 0.9551 mL | 1.9103 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.