Valsartan (CGP-48933)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
10g	$630	Check With Us
25g	$850	Check With Us
50g	$1275	Check With Us

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Cat #: V1777 CAS #: 137862-53-4 Purity ≥ 98%

Description: Valsartan (formerly CGP-48933; CGP48933; Diovan, Prova, Tareg, Miten, Nisis, Vals, Walsarta), an approved antihypertensive drug, is a potent and selective angiotensin II receptor antagonist that is used for the treatment of high blood pressure and congestive heart failure.

References: Shan H, et al. Valsartan ameliorates ageing-induced aorta degeneration via angiotensin II type 1 receptor-mediated ERK activity. J Cell Mol Med. 2014 Jun;18(6):1071-80.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	435.52
Molecular Formula	C24H29N5O3
CAS No.	137862-53-4
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 87 mg/mL (199.8 mM)r
	Water:<1 mg/mLr
	Ethanol: 87 mg/mL (199.8 mM)
Synonyms	CGP-48933; CGP 48933, CGP48933, Valsartan, Nisis, Prova, Tareg, Diovan, Miten, Vals, Walsartan

Protocol	In Vitro	Valsartan (CGP 48933) is a synthetic non-peptide angiotensin II type 1 receptor antagonist that dilates blood vessels and reduces blood pressure by blocking the action of angiotensin. Valsartan significantly decreases the expression of AT1R in ageing aorta endothelial cells

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.2961 mL	11.4805 mL	22.9611 mL	45.9221 mL
5mM	0.4592 mL	2.2961 mL	4.5922 mL	9.1844 mL
10mM	0.2296 mL	1.1481 mL	2.2961 mL	4.5922 mL
20mM	0.1148 mL	0.5740 mL	1.1481 mL	2.2961 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.