Valemetostat tosylate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1500	Check With Us
200mg	$2250	Check With Us
500mg	$3795	Check With Us

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Cat #: V32192 CAS #: 1809336-93-3 Purity ≥ 99%

Description: Valemetostat tosylate (DS3201; DS3201b; Ezharmia), the tosylate salt of Valemetostat, is an investigational and orally bioavailable dual EZH1/2 inhibitor with potential anticancer activity.

References: Daiichi Sankyo’s EZH1/2 Dual Inhibitor Valemetostat (DS-3201) Receives SAKIGAKE Designation for Treatment of Patients with Relapsed/Refractory Peripheral T-Cell Lymphoma from Japan MHLW.

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Physicochemical and Storage Information
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Stock Solution Preparation
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Molecular Weight (MW)	660.22
Molecular Formula	C33H42ClN3O7S
CAS No.	1809336-93-3
SMILES Code	O=C(C1=CC(Cl)=C(O[C@](C)([C@H]2CC[C@H](N(C)C)CC2)O3)C3=C1C)NCC4=C(C)C=C(C)NC4=O.OS(=O)(C5=CC=C(C)C=C5)=O
Synonyms	Valemetostat tosylayte; Valemetostat; DS-3201; DS 3201; DS3201; DS-3201b

Protocol	In Vitro	Valemetostat tosylate (1-1000 nM) strongly and specifically inhibits EZH1 and EZH2 with IC50 values ＜10 nM.
Protocol	In Vivo	Valemetostat tosylate (0.01 mg/g; i.p.; once) prevents the changes of H3K27me3 after exercise training.

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.5146 mL	7.5732 mL	15.1465 mL	30.2929 mL
5mM	0.3029 mL	1.5146 mL	3.0293 mL	6.0586 mL
10mM	0.1515 mL	0.7573 mL	1.5146 mL	3.0293 mL
20mM	0.0757 mL	0.3787 mL	0.7573 mL	1.5146 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.