UT-155
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $2080 | Check With Us |
| 500mg | $3250 | Check With Us |
| 1g | $4875 | Check With Us |
: Cat #: V3752 CAS #: 2031161-35-8 Purity ≥ 98%
Description: UT-155 is a potent and selective androgen receptor (AR) degrader (SARD) that markedly reduces the activity of wild-type and splice variant isoforms of AR at submicromolar doses.
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| Molecular Weight (MW) | 405.35 |
|---|---|
| Molecular Formula | C₂₀H₁₅F₄N₃O₂ |
| CAS No. | 2031161-35-8 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mMr |
| Water: <1mg/mLr | |
| Ethanol: <1mg/mL | |
| SMILES Code | O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)CN2C=CC3=C2C=CC(F)=C3 |
| Synonyms | UT-155; UT 155; UT155 |
| Protocol | In Vitro | UT-155 binds to the AR-LBD at Ki of 267 nM. UT-155 potently inhibits the R1881-induced wildtype AR transactivation with 6-10-fold higher potency than enzalutamide. While UT-155 antagonizes both wildtype and mutant ARs comparably, enzalutamide is weaker by two fold with the W742L mutant AR relative to the wild type AR. Treatment of LNCaP cells with UT-155 inhibits 0.1 nM R1881-induced PSA and FKBP5 gene expression between 10 and 100 nM with 5-10-fold better potency than enzalutamide. |
|---|---|---|
| In Vivo | Consistent with the anti-proliferative effects in vitro, UT-155 significantly inhibits the growth of 22RV1 xenograft by 53%, while, as expected, enzalutamide has no effect on the growth of the 22RV1 tumors. Tumor weights and PSA and the expression of AR and AR-SV are significantly lower in UT-155-treated animals. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.4670 mL | 12.3350 mL | 24.6700 mL | 49.3401 mL |
| 5mM | 0.4934 mL | 2.4670 mL | 4.9340 mL | 9.8680 mL |
| 10mM | 0.2467 mL | 1.2335 mL | 2.4670 mL | 4.9340 mL |
| 20mM | 0.1234 mL | 0.6168 mL | 1.2335 mL | 2.4670 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
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Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
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%
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%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.