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Uridine triacetate

This product is for research use only, not for human use. We do not sell to patients.

Uridine triacetate
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5g$1003-6 Days
10g$1503-6 Days
25g$2503-6 Days
50g$4003-6 Days

Cat #: V27879 CAS #: 4105-38-8 Purity ≥ 99%

Description: Uridine triacetate (PN-401; RG 2133; Vistogard; Vistonuridine; Xuriden; Triacetyluridine; TAU), a prodrug of uridine, is an approved medication used for treatment of hereditary orotic aciduria or to treat patients following an overdose of chemotherapy drugs 5-fluorouracil or capecitabine. The acetyl groups of Vistonuridine increase the lipophilicity of uridine, thus enhancing its transport from the gastrointestinal tract to the blood stream and its reabsorption from the renal tubules, while rendering Vistonuridine resistant to catabolism by UrdPase. Uridine triacetate was granted breakthrough therapy designation by FDA in 2015. Uridine triacetate is a prodrug of uridine.

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Molecular Weight (MW)370.31
Molecular FormulaC15H18N2O9
CAS No.4105-38-8
SynonymsPN401, RG-2133, PN 401, RG2133, PN-401, RG 2133, Tri-O-acetyluridine, Triacetyluridine, Uridine triacetate, Vistogard, Vistonuridine
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.7004 mL13.5022 mL27.0044 mL54.0088 mL
5mM0.5401 mL2.7004 mL5.4009 mL10.8018 mL
10mM0.2700 mL1.3502 mL2.7004 mL5.4009 mL
20mM0.1350 mL0.6751 mL1.3502 mL2.7004 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.