Uprosertib (GSK2141795) HCl
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1290 | Check With Us |
| 500mg | $1850 | Check With Us |
| 1g | $2775 | Check With Us |
: Cat #: V3839 CAS #: 1047635-80-2 Purity ≥ 98%
Description: Uprosertib (formerly known as GSK2141795 and GSK795), an analog of GSK2110183, is a potent, orally bioavailable and ATP-competitive Akt inhibitor with IC50 values of 180 nM, 328 nM, and 38 nM for Akt1/Akt2/Akt3, respectively.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 465.71 |
|---|---|
| Molecular Formula | C18H17Cl3F2N4O2 |
| CAS No. | 1047635-80-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: ≥ 150 mg/mLr |
| Water: N/Ar | |
| Ethanol: N/A | |
| SMILES Code | O=C(C1=CC(C2=C(Cl)C=NN2C)=C(Cl)O1)NC(CN)CC3=CC=C(F)C(F)=C3.[H]Cl |
| Synonyms | Uprosertib HCl; GSK2141795 HCl; GSK2141795 Hydrochloride; GSK 2141795; GSK795; GSK795; GSK 795 |
| Protocol | In Vitro | (In Vitro) Uprosertib inhibits Akt1/2/3 with the Kd values of 16/49/5 nM, respectively. Uprosertib potently inhibits only the PKC family members PRKACA and PRKACB as well as the cGMP-dependent protein kinase PRKG1 aqpart from the Akts. Protein targets that bind Uprosertib in the lysate show a dose-dependent reduction in binding to the kinobeads, while proteins unaffected by the drug show no reduction in binding. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1473 mL | 10.7363 mL | 21.4726 mL | 42.9452 mL |
| 5mM | 0.4295 mL | 2.1473 mL | 4.2945 mL | 8.5890 mL |
| 10mM | 0.2147 mL | 1.0736 mL | 2.1473 mL | 4.2945 mL |
| 20mM | 0.1074 mL | 0.5368 mL | 1.0736 mL | 2.1473 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.