UBROGEPANT | CAS 1374248-77-7

UBROGEPANT

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
100mg	$1500	Check With Us
250mg	$2300	Check With Us
500mg	$3450	Check With Us

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Cat #: V4385 CAS #: 1374248-77-7 Purity ≥ 98%

Description: Ubrogepant (formerly known as MK-1602; MK1602; Ubrelvy) is a novel, potent, orally bioavailable antagonist of calcitonin gene-related peptide receptor (CGRP) approved in 2019 for the acute treatment of migraine with or without aura in adults.

References: Li CC, et al. Population PK Analyses of Ubrogepant (MK-1602), a CGRP Receptor Antagonist: Enriching In-Clinic Plasma PK Sampling With Outpatient Dried Blood Spot Sampling. J Clin Pharmacol. 2017 Nov 14. doi: 10.1002/jcph.1021.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	549.54
Molecular Formula	C29H26F3N5O3
CAS No.	1374248-77-7
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.8197 mL	9.0985 mL	18.1970 mL	36.3941 mL
5mM	0.3639 mL	1.8197 mL	3.6394 mL	7.2788 mL
10mM	0.1820 mL	0.9099 mL	1.8197 mL	3.6394 mL
20mM	0.0910 mL	0.4549 mL	0.9099 mL	1.8197 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.