U73122

This product is for research use only, not for human use. We do not sell to patients.

U73122
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$850Check With Us
500mg$1350Check With Us
1g$2025Check With Us

Cat #: V0845 CAS #: 112648-68-7 Purity ≥ 98%

Description: U73122 (U 73122; U-73122) is a novel and potent phospholipase C (PLC) and 5-LO (5-lipoxygenase) inhibitor with potential anti-inflammatory activity.

References: Smith RJ, et al. Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness. J Pharmacol Exp Ther. 1990 May;253(2):688-97.

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Promise
Molecular Weight (MW)464.64
Molecular FormulaC29H40N2O3
CAS No.112648-68-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 0.01 mg/mL warmed (0.02 mM)r
Water: <1 mg/mLr
Ethanol:N/A
Solubility In Vivo2% Tween 80+saline: 5mg/mL
SMILES CodeO=C(C=C1)N(CCCCCCN[C@H]2CC[C@@]3([H])[C@]4([H])CCC5=CC(OC)=CC=C5[C@@]4([H])CC[C@]23C)C1=O
SynonymsU 73122; U73122; U73122
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.1522 mL10.7610 mL21.5220 mL43.0441 mL
5mM0.4304 mL2.1522 mL4.3044 mL8.6088 mL
10mM0.2152 mL1.0761 mL2.1522 mL4.3044 mL
20mM0.1076 mL0.5381 mL1.0761 mL2.1522 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.