Tyrphostin AG-528
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
Size | Price | Stock |
---|---|---|
250mg | $700 | Check With Us |
500mg | $1050 | Check With Us |
1g | $1575 | Check With Us |
Cat #: V16970 CAS #: 133550-49-9 Purity ≥ 98%
Description: Tyrphostin AG-528, formerly known as Tyrphostin B66, is a EGFR protein tyrosine kinase inhibitor.
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Molecular Weight (MW) | 306.32 |
---|---|
Molecular Formula | C18H14N2O3 |
CAS No. | 133550-49-9 |
SMILES Code | O=C(N1CCC2=C1C=CC=C2)/C(C#N)=C/C3=CC=C(O)C(O)=C3 |
Synonyms | Tyrphostin AG-528; Tyrphostin AG 528; Tyrphostin AG528; AG 528; AG528; AG-528; Tyrphostin B-66; Tyrphostin-B66; Tyrphostin B66 |
Protocol | In Vitro | In the present study, the interaction between drug Tyrphostin AG528 and CNT(6,6-6) nanotube by Density Functional Theory (DFT) calculations in solvent water has been investigated for the first time. According to the calculations, intermolecular hydrogen bonds take place between an active position of the molecule Tyrphostin AG528 and hydrogen atoms of the nanotube which play an important role in the stability of complex CNT(6,6- 6)/Tyrphostin AG528. The non-bonded interaction effects of the molecule Tyrphostin AG528 with CNT(6,6-6) nanotube on the electronic properties, chemical shift tensors and natural charge have also been detected. The natural bond orbital (NBO) analysis suggested that the molecule Tyrphostin AG528 as an electron donor and the CNT(6,6-6) nanotube play the role of an electron acceptor at the complex CNT(6,6-6)/Tyrphostin AG528. |
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These protocols are for reference only. InvivoChem does not
independently validate these methods.
Solvent volume to be added | Mass (the weight of a compound) | |||
---|---|---|---|---|
Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
1mM | 3.2646 mL | 16.3228 mL | 32.6456 mL | 65.2912 mL |
5mM | 0.6529 mL | 3.2646 mL | 6.5291 mL | 13.0582 mL |
10mM | 0.3265 mL | 1.6323 mL | 3.2646 mL | 6.5291 mL |
20mM | 0.1632 mL | 0.8161 mL | 1.6323 mL | 3.2646 mL |
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The dilution calculator equation
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Step One: Enter information below
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Step Two: Enter the in vivo formulation
%DMSO
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%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
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,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
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