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Tyrosine kinase inhibitor

This product is for research use only, not for human use. We do not sell to patients.

Tyrosine kinase inhibitor
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$1450To Be Confirmed
500mg$2350To Be Confirmed
1g$3525To Be Confirmed
email: [email protected]        [email protected]

Cat #: V5067 CAS #: 1021950-26-4 Purity ≥ 98%

Description: Tyrosine kinase inhibitor is novel and potent Tyrosine kinase inhibitor.

References: Paul MK, et al. Tyrosine kinase - Role and significance in Cancer. Int J Med Sci. 2004;1(2):101-115.

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Molecular Weight (MW)586.61
Molecular FormulaC31H31FN6O5
CAS No.1021950-26-4
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
SMILES CodeO=C(C1(C(N)=O)CC1)N(C2=CC=C(F)C=C2)C3=CC=C(OC4=C5C(NC(C(NCCN6CCOCC6)=O)=C5)=NC=C4)C=C3
SynonymsTyrosine kinase inhibitor; MDK-0264; MDK0264; MDK 0264; B-Raf IN, B-Raf Inhibitor;
ProtocolIn VitroTyrosine kinases are important mediators of the signaling cascade, determining key roles in diverse biological processes like growth, differentiation, metabolism and apoptosis in response to external and internal stimuli.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.7047 mL8.5236 mL17.0471 mL34.0942 mL
5mM0.3409 mL1.7047 mL3.4094 mL6.8188 mL
10mM0.1705 mL0.8524 mL1.7047 mL3.4094 mL
20mM0.0852 mL0.4262 mL0.8524 mL1.7047 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.