TVB-3166 | CAS 1533438-83-3

TVB-3166

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
100mg	$750	Check With Us
250mg	$1250	Check With Us
500mg	$1875	Check With Us

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Cat #: V16946 CAS #: 1533438-83-3 Purity ≥ 98%

Description: TVB-3166 is a novel, potent, orally bioavailable, reversible and selective inhibitor of fatty acid synthase (FASN) inhibitor (IC50s of 42 nM and 81 nM in biochemical and cellular assay, respectively. ), it acts by inducing apoptosis, inhibiting anchorage-independent cell growth under lipid-rich conditions, and inhibiting in-vivo xenograft tumor growth.

References: Ventura R, et al. Inhibition of de novo Palmitate Synthesis by Fatty Acid Synthase Induces Apoptosis in Tumor Cells by Remodeling Cell Membranes, Inhibiting Signaling Pathways, and Reprogramming Gene Expression. EBioMedicine. 2015 Jul 2;2(8):808-24.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	384.47
Molecular Formula	C24H24N4O
CAS No.	1533438-83-3
SMILES Code	N#CC1=CC=C(C2CN(C(C3=CC(C4=C(C)C(C)=NN4)=C(C)C=C3C)=O)C2)C=C1
Synonyms	TVB-3166; TVB 3166; TVB3166;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.6010 mL	13.0049 mL	26.0098 mL	52.0197 mL
5mM	0.5202 mL	2.6010 mL	5.2020 mL	10.4039 mL
10mM	0.2601 mL	1.3005 mL	2.6010 mL	5.2020 mL
20mM	0.1300 mL	0.6502 mL	1.3005 mL	2.6010 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.