Trifarotene (CD5789)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$1550	Check With Us
500mg	$2150	Check With Us
1g	$3225	Check With Us

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Cat #: V16789 CAS #: 895542-09-3 Purity ≥ 98%

Description: Trifarotene (CD5789; trade name Aklief) is a gamma retinoic acid receptor (RAR) agonist under approved in 2019 as a topical cream for the treatment of skin disorders, including acne vulgaris, cutaneous t-cell lymphoma and lamellar ichthyosis.

References: Etienne Thoreau, et al. Structure-based design of Trifarotene (CD5789), a potent and selective RARγ agonist for the treatment of acne. Bioorg Med Chem Lett. 2018 Jun 1;28(10):1736-1741.

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Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	459.58
Molecular Formula	C29H33NO4
CAS No.	895542-09-3
SMILES Code	O=C(C1=CC=C(C2=CC=C(OCCO)C(C3=CC=C(N4CCCC4)C(C(C)(C)C)=C3)=C2)C=C1)O
Synonyms	Trifarotene; CD5789; CD-5789; CD 5789. Aklief;

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.1759 mL	10.8795 mL	21.7590 mL	43.5180 mL
5mM	0.4352 mL	2.1759 mL	4.3518 mL	8.7036 mL
10mM	0.2176 mL	1.0879 mL	2.1759 mL	4.3518 mL
20mM	0.1088 mL	0.5440 mL	1.0879 mL	2.1759 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.