TRC253
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1150 | Check With Us |
| 500mg | $1750 | Check With Us |
| 1g | $2625 | Check With Us |
: Cat #: V3368 CAS #: 2110428-64-1 (HCl) Purity ≥ 99%
Description: TRC-253, also known as JNJ-63576253, is a novel,potent and orally active androgen receptor antagonist.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 538.9742 |
|---|---|
| Molecular Formula | C23H22ClF3N6O2S |
| CAS No. | 2110428-64-1 (HCl) |
| Synonyms | TRC-253; TRC253; TRC 253; JNJ63576253 hydrochloride, JNJ 63576253; JNJ63576253; JNJ 63576253; JNJ63576253 HCl |
| Protocol | In Vitro | JNJ-63576253 (0.0003-100 μM； 5) Inhibit the growth of VCaP cells, IC50 is 265 nM |
|---|---|---|
| In Vivo | JNJ-63576253 (30 mg/kg； Oral administration once daily for 72 days) significantly inhibited the growth of mouse prostate LNCaP SRα F877L tumors | |
| Animal model | Castrated SHO mice with prostate LNCaP SRα F877L tumor | |
| Dosages | 30 mg/kg | |
| Administration | P.o. once daily for 72 days |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.8554 mL | 9.2769 mL | 18.5538 mL | 37.1075 mL |
| 5mM | 0.3711 mL | 1.8554 mL | 3.7108 mL | 7.4215 mL |
| 10mM | 0.1855 mL | 0.9277 mL | 1.8554 mL | 3.7108 mL |
| 20mM | 0.0928 mL | 0.4638 mL | 0.9277 mL | 1.8554 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.