TPT-260 | CAS 769856-81-7 (free base)

TPT-260

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5mg	$70	3-6 Days
10mg	$100	3-6 Days
25mg	$150	3-6 Days
50mg	$240	3-6 Days
100mg	$420	3-6 Days
250mg	$700	3-6 Days
500mg	$1150	3-6 Days
1g	$1750	3-6 Days

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Cat #: V3404 CAS #: 769856-81-7 (free base) Purity ≥ 98%

Description: TPT-260 (also known as TPU260 and R55) is a thiophene thiourea derivative with molecule weight 260.00 in free base form; There is no formal name yet, it is temporally called as TPT-260. TPT260 acts as a chaperone to stabilize the retromer complex against thermal denaturation (Kd = ~ 5 µM). In cultured hippocampal neurons, TPT-260 dose-dependently increases the level of retromer proteins, redirects APP from the endosome, and reduces the formation of pathogenic APP. Similar products include: TPT-197; TPT-260; TPT-172 (R33; CAS#: 32415-42-2) etc.

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CAS No.	769856-81-7 (free base)
Storage	-20℃ for 3 years in powder form
Storage	-80℃ for 2 years in solvent

Related Biological Data

Identification of a retromer stabilizing pharmacological chaperone. Nat Chem Biol. 2014 Jun;10(6):443-9.	The pharmacological chaperone increases retromer levels in neurons. Nat Chem Biol. 2014 Jun;10(6):443-9.	The pharmacological chaperone decreases Aβ peptide accumulation and reduces the pathogenic pathway of APP. Nat Chem Biol. 2014 Jun;10(6):443-9.
The pharmacological chaperone shifts the endosomal localization of APP and SorL1. Nat Chem Biol. 2014 Jun;10(6):443-9.	The pharmacological chaperone specifically modulates Aβ production through the retromer pathway.

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

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The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

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Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.