TPPB

This product is for research use only, not for human use. We do not sell to patients.

TPPB
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$3150Check With Us
250mg$5250Check With Us
500mg$7875Check With Us

Cat #: V16673 CAS #: 497259-23-1 Purity ≥ 98%

Description: TPPB is a novel, potent and cell-permeable benzolactam-derived protein kinase C (PKC) activator (Ki = 11.9 nM) wuth neuroprotective effects.

References: Kozikowski AP, et al. New amide-bearing benzolactam-based protein kinase C modulators induce enhanced secretion of the amyloid precursor protein metabolite sAPPalpha. J Med Chem. 2003 Jan 30;46(3):364-73.

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Product Promise

Promise
Molecular Weight (MW)501.54
Molecular FormulaC27H30F3N3O3
CAS No.497259-23-1
SMILES CodeO=C(NC1=CC=C2N(C)[C@@H](C(C)C)C(N[C@H](CO)CC2=C1)=O)/C=C/C=C/C3=CC=C(C(F)(F)F)C=C3           
SynonymsTPPB
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.9939 mL9.9693 mL19.9386 mL39.8772 mL
5mM0.3988 mL1.9939 mL3.9877 mL7.9754 mL
10mM0.1994 mL0.9969 mL1.9939 mL3.9877 mL
20mM0.0997 mL0.4985 mL0.9969 mL1.9939 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.