TP-064
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $850 | To Be Confirmed |
| 200mg | $1275 | To Be Confirmed |
| 500mg | $2150 | To Be Confirmed |
: Cat #: V16651 CAS #: 2080306-20-1 Purity ≥ 99%
Description: TP-064 (TP064) is a novel and potent inhibitor of proteinarginine methyltransferase 4 (PRMT4) CARM1 with anticancer and anti-inflammatory activity.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 458.60 |
|---|---|
| Molecular Formula | C28H34N4O2 |
| CAS No. | 2080306-20-1 |
| SMILES Code | O=C(N(C)CC1=CC(C2CCN(CCNC)CC2)=NC=C1)C3=CC=CC(OC4=CC=CC=C4)=C3 |
| Synonyms | TP-064; TP 064; TP064 |
| Protocol | In Vitro | TP-064 (10 nM-10 μM; 6 days) treatment inhibits the growth of NCI-H929, RPMI8226, and MM.1R cells in a dose-dependent manner, but had no effect on acute myeloid leukemia, colon cancer, or lung cancer cell lines. TP-064 (0.03-3 μM; 72 hours) treatment reduces dimethyl-BAF155 level in a dose-dependent manner in both TP-064-sensitive and -insensitive cells. TP-064 (1 μM; 72 hours) treatment reduces the proportion of NCI-H929 cells in S and G2/M phases while increasing the G1 phase fraction. |
|---|---|---|
| In Vivo | TP-064 (10 mg/kg; i.p.; 3 times in 5 days) induces peritonitis-associated neutrophilia in C57BL/6 mice. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1805 mL | 10.9027 mL | 21.8055 mL | 43.6110 mL |
| 5mM | 0.4361 mL | 2.1805 mL | 4.3611 mL | 8.7222 mL |
| 10mM | 0.2181 mL | 1.0903 mL | 2.1805 mL | 4.3611 mL |
| 20mM | 0.1090 mL | 0.5451 mL | 1.0903 mL | 2.1805 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.