TP-0427736 HCl

This product is for research use only, not for human use. We do not sell to patients.

TP-0427736 HCl
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
5mg$1603-6 Days
10mg$2703-6 Days
50mg$5403-6 Days
email: [email protected]        [email protected]

Cat #: V49173 CAS #: 2459963-17-6 Purity ≥ 99%

Description: TP0427736 HCl is a potent inhibitor of ALK5 kinase activity with IC50 of 2.72 nM, which is 300-fold greater than the inhibition of ALK3 (IC50 for ALK3 inhibition is 836 nM). TP0427736 HCl also inhibits Smad2/3 phosphorylation induced by TGF-β1 in A549 cells with IC50 of 8.68 nM. TP0427736 HCl

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Molecular Weight (MW)334.8469
Molecular FormulaC14H11CLN4S2
CAS No.2459963-17-6
Storage

Powder      -20°C    3 years

                     4°C     2 years

In solvent   -80°C    6 months

                  -20°C    1 month

Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.9864 mL14.9322 mL29.8644 mL59.7288 mL
5mM0.5973 mL2.9864 mL5.9729 mL11.9458 mL
10mM0.2986 mL1.4932 mL2.9864 mL5.9729 mL
20mM0.1493 mL0.7466 mL1.4932 mL2.9864 mL
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
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Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.