Topiroxostat
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $520 | Check With Us |
| 1g | $950 | Check With Us |
| 5g | $2405 | Check With Us |
: Cat #: V2925 CAS #: 577778-58-6 Purity ≥ 98%
Description: Topiroxostat (formerly FYX-051; FYX051; Brand names: Topiloric and Uriadec) is a novel and potent xanthine oxidoreductase (XOR) inhibitor with urate lowering effects.
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| Molecular Weight (MW) | 248.24 |
|---|---|
| Molecular Formula | C13H8N6 |
| CAS No. | 577778-58-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 23.5 mg/mLr |
| Water: <1 mg/mLr | |
| Ethanol: N/A | |
| SMILES Code | N#CC1=NC=CC(C2=NNC(C3=CC=NC=C3)=N2)=C1 |
| Synonyms | FYX051; FYX-051; FYX 051; Trade names: Topiloric; Uriadec; Topiroxostat. |
| Protocol | In Vitro | These potent and more sustained effects of Topiroxostat (FYX-051, compound 39) have been confirmed by a crystallographic analysis of XOR-Topiroxostat complex. The cyano group of Topiroxostat has been reported to play an important role in the binding activity between Topiroxostat and XOR. This is attributable to the formation of a hydrogen bond between Asn 768 of XOR and the cyano group of Topiroxostat. |
|---|---|---|
| In Vivo | Topiroxostat (FYX-051; 0.03-10 mg/kg; oral administration; for 1 hour; male Wistar/ST strain rats) treatment shows a potent and long-lasting hypouricemic effect in a rat model of potassium oxonate-induced hyperuricemia. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 4.0284 mL | 20.1418 mL | 40.2836 mL | 80.5672 mL |
| 5mM | 0.8057 mL | 4.0284 mL | 8.0567 mL | 16.1134 mL |
| 10mM | 0.4028 mL | 2.0142 mL | 4.0284 mL | 8.0567 mL |
| 20mM | 0.2014 mL | 1.0071 mL | 2.0142 mL | 4.0284 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.