Tomeglovir
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1160 | Check With Us |
| 500mg | $1650 | Check With Us |
| 1g | $2475 | Check With Us |
: Cat #: V4218 CAS #: 233254-24-5 Purity ≥ 98%
Description: Tomeglovir (also known as BAY-38-4766) is a novel, potent and non-nucleoside anti-CMV (cytomegalovirus) agent which inhibits processing of viral DNA-concatemers with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 441.54 |
|---|---|
| Molecular Formula | C23H27N3O4S |
| CAS No. | 233254-24-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | O=C(NC1=CC=C(NS(=O)(C2=C3C=CC=C(N(C)C)C3=CC=C2)=O)C=C1)C(C)(C)CO |
| Synonyms | Tomeglovir; BAY-38-4766; BAY 38-4766; BAY38-4766; BAY 38,4766; BAY38,4766; BAY-384766; BAY 384766; BAY384766; BAY-38,4766; |
| Protocol | In Vitro | Tomeglovir (BAY 38-4766) is a potent anti-CMV agent, with IC50s of 0.34 μM and 0.039 μM for HCMV and MCMV. Tomeglovir also suppresses HELF and NIH 3T3 cells, with CC50s of 85 μM and 62.5 μM, respectively. |
|---|---|---|
| In Vivo | Tomeglovir (BAY 38-4766; 3, 10, 30, 100 mg/kg, p.o.) dose-dependently reduces MCMV-DNA in salivary glands, livers and kidneys of MCMV-infected NOD-SCID mice, and prolongs the survival of the mice. Tomeglovir (10, 25 and 50 mg/kg) shows antiviral activity in the hollow fiber mouse model. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2648 mL | 11.3240 mL | 22.6480 mL | 45.2960 mL |
| 5mM | 0.4530 mL | 2.2648 mL | 4.5296 mL | 9.0592 mL |
| 10mM | 0.2265 mL | 1.1324 mL | 2.2648 mL | 4.5296 mL |
| 20mM | 0.1132 mL | 0.5662 mL | 1.1324 mL | 2.2648 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.