Tolrestat (AY-27773)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $650 | Check With Us |
| 250mg | $1250 | Check With Us |
| 500mg | $1875 | Check With Us |
: Cat #: V14560 CAS #: 82964-04-3 Purity ≥ 98%
Description: Tolrestat (AY27773) is a novel, potent, orally bioactive aldose reductase inhibitor with IC50 of 35 nM.
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| Molecular Weight (MW) | 357.35 |
|---|---|
| Molecular Formula | C16H14F3NO3S |
| CAS No. | 82964-04-3 |
| SMILES Code | O=C(O)CN(C(C1=C2C=CC(OC)=C(C(F)(F)F)C2=CC=C1)=S)C |
| Synonyms | AY-27,773; AY 27,773; AY27,773; Alredase; Tolrestatum; Lorestat; AY 27773; AY-27773; AY27773; Tolrestat; |
| Protocol | In Vitro | Tolrestat (1.8 mg/kg per day) causes a reversal to normal RBC sorbitol levels diabetic rats. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.7984 mL | 13.9919 mL | 27.9838 mL | 55.9675 mL |
| 5mM | 0.5597 mL | 2.7984 mL | 5.5968 mL | 11.1935 mL |
| 10mM | 0.2798 mL | 1.3992 mL | 2.7984 mL | 5.5968 mL |
| 20mM | 0.1399 mL | 0.6996 mL | 1.3992 mL | 2.7984 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.