Toceranib phosphate
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 5g | $490 | In Stock |
| 10g | $860 | In Stock |
| 20g | $1290 | In Stock |
: Cat #: V3699 CAS #: 874819-74-6 Purity ≥ 98%
Description: Toceranib phosphate (formerly known as PHA291639; SU11654), phosphate salt of Toceranib, is a novel and potent receptor tyrosine kinase (RTK) inhibitor with antineoplastic/anticancer activities.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 494.46 |
|---|---|
| Molecular Formula | C22H28FN4O6P |
| CAS No. | 874819-74-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 2 mg/mL (4.0 mM)r |
| Water: 2 mg/mL (4.0 mM)r | |
| Ethanol: <1mg/mL | |
| SMILES Code | O=C(C1=C(C)NC(/C=C2C(NC3=C\2C=C(F)C=C3)=O)=C1C)NCCN4CCCC4.O=P(O)(O)O |
| Synonyms | SU-11654 phosphate; PHA291639 phosphate; SU 11654; PHA-291639 phosphate; SU11654; PHA 291639; Toceranib phosphate; Trade name: Palladia. |
| Protocol | In Vitro | Toceranib phosphate (PHA 291639 phosphate) is a selective inhibitor of the tyrosine kinase activity of several members of the split kinase RTK family, including PDGFR and Flk-1/KDR, with Kis of 5 and 6 nM, respectively. |
|---|---|---|
| In Vivo | Administration of Toceranib phosphate (PHA 291639 phosphate) significantly decreases the number and percentage of Treg in the peripheral blood of dogs with cancer. Dogs receiving Toceranib phosphate (PHA 291639 phosphate) and cyclophosphamide (CYC) demonstrate a significant increase in serum concentrations of IFN-γ, which is inversely correlated with Treg numbers after 6 weeks of combination treatment. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0224 mL | 10.1120 mL | 20.2241 mL | 40.4482 mL |
| 5mM | 0.4045 mL | 2.0224 mL | 4.0448 mL | 8.0896 mL |
| 10mM | 0.2022 mL | 1.0112 mL | 2.0224 mL | 4.0448 mL |
| 20mM | 0.1011 mL | 0.5056 mL | 1.0112 mL | 2.0224 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.