TMN355
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1250 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V2374 CAS #: 1186372-20-2 Purity ≥ 99%
Description: TMN-355 (also known as Compound 3i) is a novel and potent CypA(cyclophilin A ) inhibitor( IC50 =1.52 nM),
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 380.80 |
|---|---|
| Molecular Formula | C21H14ClFN2O2 |
| CAS No. | 1186372-20-2 |
| SMILES Code | O=C(NC(NC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=C(F)C=CC=C4Cl |
| Synonyms | TMN 355; TMN355; TMN-355 |
| Protocol | In Vitro | TMN 355 (0.5-10 μM; 3-9 hours) results in 75.9% reduction of cyclophilin A protein expression. And 1 μM TMN 355 inhibits cyclophilin A after 6 h of activation. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6261 mL | 13.1303 mL | 26.2605 mL | 52.5210 mL |
| 5mM | 0.5252 mL | 2.6261 mL | 5.2521 mL | 10.5042 mL |
| 10mM | 0.2626 mL | 1.3130 mL | 2.6261 mL | 5.2521 mL |
| 20mM | 0.1313 mL | 0.6565 mL | 1.3130 mL | 2.6261 mL |
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The dilution calculator equation
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.