Tirofiban hydrochloride (L700462)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $700 | Check With Us |
| 500mg | $1200 | Check With Us |
| 1g | $1800 | Check With Us |
: Cat #: V3822 CAS #: 142373-60-2 Purity ≥ 98%
Description: Tirofiban hydrochloride (also known as L700462 or MK383) is a novel non-peptide antagonist of glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) that is used as an antiplatelet drug.
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- Physicochemical and Storage Information
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- Related Biological Data
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| Molecular Weight (MW) | 477.05 |
|---|---|
| Molecular Formula | C22H36N2O5S.ClH |
| CAS No. | 142373-60-2 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 95 mg/mL (191.89 mM)r |
| Water: 95 mg/mL (191.89 mM)r | |
| Ethanol: 95 mg/mL (191.89 mM) | |
| Solubility In Vivo | O=C(O)[C@H](CC1=CC=C(OCCCCC2CCNCC2)C=C1)NS(=O)(CCCC)=O.[H]Cl |
| Synonyms | Tirofiban; Tirofiban hydrochloride; MK-383 Hydrochloride; Aggrastat; L 700462; L-700,462; MK-383; MK 383; MK383 |
| Protocol | In Vitro | Tirofiban hydrochloride (0.25, 1, 3 μg/mL; 72 hours) increases proliferation of HAEC cells. Tirofiban hydrochloride (24 hours) closes the scratch of HUVECs migration within 18 hours. Tirofiban hydrochloride (0.25, 1 μg/mL; 1 hour) induces production of VEGF after 30 minutes which can stimulates proliferation of endothelial cells |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.0962 mL | 10.4811 mL | 20.9622 mL | 41.9243 mL |
| 5mM | 0.4192 mL | 2.0962 mL | 4.1924 mL | 8.3849 mL |
| 10mM | 0.2096 mL | 1.0481 mL | 2.0962 mL | 4.1924 mL |
| 20mM | 0.1048 mL | 0.5241 mL | 1.0481 mL | 2.0962 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
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Volume(start)
V1
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C2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.