Tiotropium Bromide hydrate (BA-679 BR)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$700	Check With Us
5g	$2100	Check With Us
10g	$3150	Check With Us

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Cat #: V1160 CAS #: 139404-48-1 Purity ≥ 98%

Description: Tiotropium Bromide hydrate (PUR-0200; BA-679BR; BA679BR; PUR0200; Spiriva), the monohydrate form of tiotropium bromide, is an anticholinergic and bronchodilator and a muscarinic receptor antagonist used as a long-acting bronchodilator for the management of chronic obstructive pulmonary disease (COPD).

References: Respir Med. 2007 Nov;101(11):2386-94

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Physicochemical and Storage Information
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Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	490.43
Molecular Formula	C19H22NO4S2.Br.xH2O
CAS No.	139404-48-1
Storage	-20℃ for 3 years in powder formrr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 8 mg/mL (16.3 mM)rr
	Water: <1 mg/mLrr
	Ethanol: <1 mg/mL
SMILES Code	C[N+]1([C@@H]2CC(C[C@H]1[C@H]3[C@@H]2O3)OC(=O)C(C4=CC=CS4)(C5=CC=CS5)O)C.[Br-]
Synonyms	BA 679BR; PUR-0200; BA 679BR; BA-679BR; BA679BR; PUR0200; PUR 0200; Tiotropium bromide, trade name: Spiriva.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0390 mL	10.1951 mL	20.3903 mL	40.7805 mL
5mM	0.4078 mL	2.0390 mL	4.0781 mL	8.1561 mL
10mM	0.2039 mL	1.0195 mL	2.0390 mL	4.0781 mL
20mM	0.1020 mL	0.5098 mL	1.0195 mL	2.0390 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.