Tiludronate disodium

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
50mg	$450	Check With Us
100mg	$750	Check With Us
200mg	$2025	Check With Us

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Cat #: V16456 CAS #: 149845-07-8 Purity ≥ 98%

Description: Tiludronate (Tiludronate disodium; Tiludronic Acid disodium) is a novel and potent bisphosphonate agent which prevents postmenopausal bone loss and is used for treatment of Paget's disease of bone (osteitis deformans) in human medicine.

References: Bonjour JP, et al. Tiludronate: bone pharmacology and safety. Bone. 1995;17(5 Suppl):473S-477S.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	362.57
Molecular Formula	C7H7ClNa2O6P2S
CAS No.	149845-07-8
SMILES Code	O=P(O)(C(SC1=CC=C(Cl)C=C1)P([O-])(O)=O)[O-].[Na+].[Na+]
Synonyms	Tiludronate disodium; Tiludronic Acid disodium; Tiludronic acid; Skelid; Tildren

Protocol	In Vitro	The ability of Tiludronate to inhibit proton transport is 5-fold higher in kidney-derived vesicles (IC50=1.1 mM) and 10,000-fold higher in vesicles derived from osteoclasts (IC50=466 nM). Tiludronate also potently inhibits proton transport in yeast microsomal preparations (IC50=3.5 microM) and inhibits the activity of purified yeast V-ATPase. The inhibition of the osteoclast V-ATPase-mediated proton transport by Tiludronate is rapid, pH-dependent, and reversible
Protocol	In Vivo	Tiludronate exerts a dose-dependent inhibitory activity on bone resorption. Tiludronate could act on mature osteoclasts by reducing their capacity to secrete proton into the resorption space and also by favoring their detachment from the bone matrix. Tiludronate is also tested in other models of osteoporosis. In the castrated male rat model, Tiludronate (5-200 mg/kg; p.o.) prevents the decrease in the skeletal mass, assessed physically by measuring the bone weight and density or chemically by determining the calcium and phosphate content

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.7581 mL	13.7904 mL	27.5809 mL	55.1618 mL
5mM	0.5516 mL	2.7581 mL	5.5162 mL	11.0324 mL
10mM	0.2758 mL	1.3790 mL	2.7581 mL	5.5162 mL
20mM	0.1379 mL	0.6895 mL	1.3790 mL	2.7581 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.