Tie2 kinase inhibitor
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1240 | Check With Us |
| 500mg | $1950 | Check With Us |
| 1g | $2925 | Check With Us |
: Cat #: V0632 CAS #: 948557-43-5 Purity ≥ 98%
Description: Tie2 kinase inhibitor, optimized from SB-203580, is a reversible, selective and ATP-competitive Tie2 inhibitor with potential antitumor activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 439.53 |
|---|---|
| Molecular Formula | C26H21N3O2S |
| CAS No. | 948557-43-5 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 35 mg/mL (79.6 mM)r |
| Water: <1 mg/mLr | |
| Ethanol: <1 mg/mL | |
| Solubility In Vivo | 2% Cremophor EL, 2% N,N-dimethylacetamide: 30 mg/mL |
| SMILES Code | O=S(C1=CC=C(C2=NC(C3=CC=C4C=C(OC)C=CC4=C3)=C(C5=CC=NC=C5)N2)C=C1)C |
| Synonyms | Tie2-inhibitor-5; Tie2 IN 5; Tie2IN5; Tie2 kinase inhibitor 5; Tie2-IN-5; Tie2 inhibitor 5; Compound 5; |
| Protocol | In Vitro | Tie2 kinase inhibitor 1 inhibits tunica internal endothelial cell kinase 2 (Tie2). Tie2 kinase inhibitor 1 (compound 5) has an IC50 of 50 μM for p38 and has moderate to excellent cellular activities (cell IC50=232 nM). |
|---|---|---|
| In Vivo | Tie2 kinase inhibitor 1 (intraperitoneally; 50 mg/kg; twice a week for 6 weeks) results in statistically significant reductions in tumor volume by day 15. Tie2 kinase inhibitor 1 results in a 61% reduction in tumor volume by day 20, and reduces tumor volume by 45% by 6 weeks. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.2752 mL | 11.3758 mL | 22.7516 mL | 45.5032 mL |
| 5mM | 0.4550 mL | 2.2752 mL | 4.5503 mL | 9.1006 mL |
| 10mM | 0.2275 mL | 1.1376 mL | 2.2752 mL | 4.5503 mL |
| 20mM | 0.1138 mL | 0.5688 mL | 1.1376 mL | 2.2752 mL |
The molarity calculator equation
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The dilution calculator equation
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Step One: Enter information below
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Average weight of animals g
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Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
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Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
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mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.