Thapsigargin
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 25mg | $1200 | To Be Confirmed |
| 50mg | $2000 | To Be Confirmed |
| 100mg | $3000 | To Be Confirmed |
: Cat #: V9143 CAS #: 67526-95-8 Purity ≥ 98%
Description: Thapsigargin is a novel and potent non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) and an Endoplasmic Reticulum (ER) stress inducing agent.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
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- Quality Control Documentation
| Molecular Weight (MW) | 650.75 |
|---|---|
| Molecular Formula | C34H50O12 |
| CAS No. | 67526-95-8 |
| SMILES Code | CCCCCCCC(O[C@@H]1[C@@H](OC(/C(C)=CC)=O)C(C)=C2[C@@]1([H])[C@@](C)(OC(C)=O)C[C@H](OC(CCC)=O)[C@@]([C@@]3(O)C)(O)[C@@]2([H])OC3=O)=O |
| Synonyms | Thapsigargin |
| Protocol | In Vitro | Thapsigargin (0.001-1 μM； Duration 2 and 4 days) Inhibits cell proliferation of synovial cells of MH7A human rheumatoid arthritis in a time- and dose-dependent manner |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5367 mL | 7.6834 mL | 15.3669 mL | 30.7338 mL |
| 5mM | 0.3073 mL | 1.5367 mL | 3.0734 mL | 6.1468 mL |
| 10mM | 0.1537 mL | 0.7683 mL | 1.5367 mL | 3.0734 mL |
| 20mM | 0.0768 mL | 0.3842 mL | 0.7683 mL | 1.5367 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.