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| Size | Price | Stock |
|---|---|---|
| 5mg | $100 | 3-6 Days |
| 10mg | $150 | 3-6 Days |
| 25mg | $250 | 3-6 Days |
| 50mg | $400 | 3-6 Days |
| 100mg | $650 | 3-6 Days |
| 250mg | $1150 | 3-6 Days |
| 500mg | $1750 | 3-6 Days |
: Cat #: V34667 CAS #: 313520-94-4 Purity ≥ 99%
Description: TH-263 is a diaryl sulfonamide derivativeused as a negative control for the type III allosteric LIM-kinase (LIMK) inhibitors TH-257, TH-255 and TH-251. LIM kinases belong to the family of cytoplasmic tyrosine-like kinases with dual specificity (serine/threonine and tyrosine). However, known LIMK substrate are usually phosphorylated at serine and threonine residues LIM kinases comprises LIM kinase 1 (LIMK1) and LIM kinase 2 (LIMK2) which show 50% sequence identity in human. Both LIMK1 and LIMK2 present with a unique domain organization containing two N-terminal LIM domains, a PDZ domain, a proline/serine-rich domain and a C-terminal kinase domain.
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| Molecular Weight (MW) | 380.462 |
|---|---|
| Molecular Formula | C21H20N2O3S |
| CAS No. | 313520-94-4 |
| SMILES Code | O=C(NCC1=CC=CC=C1)C2=CC=C(S(=O)(NCC3=CC=CC=C3)=O)C=C2 |
| Synonyms | TH-263; TH 263; TH263 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.6284 mL | 13.1419 mL | 26.2838 mL | 52.5677 mL |
| 5mM | 0.5257 mL | 2.6284 mL | 5.2568 mL | 10.5135 mL |
| 10mM | 0.2628 mL | 1.3142 mL | 2.6284 mL | 5.2568 mL |
| 20mM | 0.1314 mL | 0.6571 mL | 1.3142 mL | 2.6284 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.