Terizidone | CAS 25683-71-0

Terizidone

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Cat #: V5360 CAS #: 25683-71-0 Purity ≥ 99%

Description: Terizidone (Terivalidin), a derivate of cycloserine (CS), is a bacteriostatic second-line drug for multi-drug-resistant tuberculosis (MDR-TB) in conjunction with other second-line drugs. It is used internationally, but is not currently approved in the United States. It is a combination of two molecules of CS. The MOA includes competitively inhibiting l-alanine racemase and d-alanine ligase to inhibit cell wall synthesis. Reference: https://doi.org/10.1016/bs.seda.2019.08.010

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Stock Solution Preparation
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Molecular Weight (MW)	302.29
Molecular Formula	C14H14N4O4
CAS No.	25683-71-0

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	3.3081 mL	16.5404 mL	33.0808 mL	66.1616 mL
5mM	0.6616 mL	3.3081 mL	6.6162 mL	13.2323 mL
10mM	0.3308 mL	1.6540 mL	3.3081 mL	6.6162 mL
20mM	0.1654 mL	0.8270 mL	1.6540 mL	3.3081 mL

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.