Tenofovir Alafenamide (GS-7340)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
1g	$580	Check With Us
5g	$1850	Check With Us
10g	$2775	Check With Us

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Cat #: V1818 CAS #: 379270-37-8 Purity ≥ 98%

Description: Tenofovir Alafenamide (formerly also known as TAF and GS-7340) is a novel prodrug of tenofovir, which is a potent reverse transcriptase inhibitor [nucleotide reverse transcriptase inhibitor (NRTIs)], it is used for the treatment of HIV and Hepatitis B.

References: Tenofovir alafenamide (GS-7340) hemifumarate is an amidation prodrug of Tenofovir with good oral bioavailability and plasma stability compared to Tenofovir disoproxil fumarate (TDF)

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	476.47
Molecular Formula	C21H29N6O5P
CAS No.	379270-37-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 95 mg/mL (199.4 mM)r
	Water:<1 mg/mLr
	Ethanol: 95 mg/mL (199.4 mM)
Synonyms	GS7340; GS-7340; GS 7340; Genvoya

Protocol	In Vivo	Tenofovir alafenamide (GS-7340) hemifumarate is an amidation prodrug of Tenofovir with good oral bioavailability and plasma stability compared to Tenofovir disoproxil fumarate (TDF)

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	2.0988 mL	10.4938 mL	20.9877 mL	41.9754 mL
5mM	0.4198 mL	2.0988 mL	4.1975 mL	8.3951 mL
10mM	0.2099 mL	1.0494 mL	2.0988 mL	4.1975 mL
20mM	0.1049 mL	0.5247 mL	1.0494 mL	2.0988 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.