Tenapanor HCl

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
250mg	$980	Check With Us
500mg	$1580	Check With Us
1g	$2370	Check With Us

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Cat #: V4283 CAS #: 1234365-97-9 Purity ≥ 98%

Description: Tenapanor 2HCl (formerly AZD-1722; AZD1722; RDX-5791; RDX 5791; Ibsrela), the dihydrochloride salt of Tenapanor, is a novel and potent inhibitor of the sodium-proton (Na(+)/H(+)) exchanger NHE3 approved in 2019 for the treatment of irritable bowel syndrome with constipation (IBS-C).

References: King AJ, et al. Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability. Sci Transl Med. 2018 Aug 29;10(456):eaam6474.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	1217.97
Molecular Formula	C50H68Cl6N8O10S2
CAS No.	1234365-97-9
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent

Protocol	In Vivo	Tenapanor hydrochloride (0.15, 0.5 mg/kg; p.o.) reduces passive paracellular phosphate absorption in rats
	Animal model	Rats (intestinal loop model)
	Dosages	0.15, 0.5 mg/kg

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	0.8210 mL	4.1052 mL	8.2104 mL	16.4208 mL
5mM	0.1642 mL	0.8210 mL	1.6421 mL	3.2842 mL
10mM	0.0821 mL	0.4105 mL	0.8210 mL	1.6421 mL
20mM	0.0411 mL	0.2053 mL	0.4105 mL	0.8210 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.