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Teduglutide Acetate

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Teduglutide Acetate
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Cat #: V34647 CAS #: 287714-30-1 Purity ≥ 99%

Description: Teduglutide Acetate (Gattex; Revestive) is a polypeptide composed of 33-amino acids. It is a glucagon-like peptide-2 (GLP-2) analog that has been approved as an orphan drug for use in the treatment of SBS-short bowel syndrome. Teduglutide works by promoting mucosal growth and possibly restoring gastric emptying and secretion. Teduglutide differs from naturally occurring GLP-2 by a single amino acid: an alanine replaced by a glycine, which blocks breaking down of the molecule by dipeptidyl peptidase and increases the half-life from 7 minutes (GLP-2) to about 2 hours, while retaining its biological activity. Reference: Therapeutic Advances in Gastroenterology. 2012, 5 (3): 159–71. doi:10.1177/1756283X11436318.

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CAS No.287714-30-1
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.