TCS-OX2-29
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1350 | Check With Us |
| 500mg | $2160 | Check With Us |
| 1g | $3240 | Check With Us |
: Cat #: V2861 CAS #: 372523-75-6 Purity ≥ 98%
Description: TCS-OX2-29 (TCS-OX229, TCS-OX-229), discovered from high throughput screening (HTS), is a potent, selective and non-peptide OX2 (orexin) receptor antagonist with potential usefulness in the treatment of insomnia.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 397.51 |
|---|---|
| Molecular Formula | C₂₃H₃₁N₃O₃ |
| CAS No. | 372523-75-6 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 10 mM in DMSOr |
| Water: <1 mg/mLr | |
| Ethanol: NA | |
| SMILES Code | CC(C)(C)[C@H](NCC1=CC=NC=C1)C(N2CC3=C(C=C(OC)C(OC)=C3)CC2)=O |
| Synonyms | TCSOX 229, TCS OX-229, TCSOX229, TCS OX229, TCSOX 229, TCS OX2 29, TCS-OX229, TCS OX2 29, TCS-OX2-29, TCS OX2 29 |
| Protocol | In Vitro | TCS-OX2-29 inhibits orexin A induced IP3 accumulation and ERK1/2 phosphorylation in CHO cells transfected with the OX2 receptor |
|---|---|---|
| In Vivo | TCS-OX2-29 (5-10 mg/kg; intraperitoneal injection; adult male NMRI mice) treatment suppresses conditioned place preference (CPP) acquisition and expression in both naïve and dependent mice significantly | |
| Animal model | 440 adult male NMRI mice (25-30 g) | |
| Dosages | 5 mg/kg and 10 mg/kg | |
| Administration | Intraperitoneal injection (Pharmacokinetic study) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.5157 mL | 12.5783 mL | 25.1566 mL | 50.3132 mL |
| 5mM | 0.5031 mL | 2.5157 mL | 5.0313 mL | 10.0626 mL |
| 10mM | 0.2516 mL | 1.2578 mL | 2.5157 mL | 5.0313 mL |
| 20mM | 0.1258 mL | 0.6289 mL | 1.2578 mL | 2.5157 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.