TBK1/IKKε-IN-5
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1850 | In Stock |
| 500mg | $2600 | In Stock |
| 1g | $3900 | In Stock |
: Cat #: V32070 CAS #: 1893397-65-3 Purity ≥ 99%
Description: TBK1/IKKε-IN-5 (compound 1 in patent WO 2016049211) is a potent dual TBK1 and IKKε inhibitor, with IC50 of 1 nM and 5.6 nM for TBK1 and IKKε, respectively.
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- Related Biological Data
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| Molecular Weight (MW) | 513.59 |
|---|---|
| Molecular Formula | C28H31N7O3 |
| CAS No. | 1893397-65-3 |
| SMILES Code | N#CC1=CC(C2=NC(NC3=CC=C(N4CCN(C5COC5)CC4)C=C3)=NC=N2)=CC=C1OC6CCOCC6 |
| Synonyms | TBK1/IKKε-IN-5; QUN97653; QUN-97653; QUN 97653; |
| Protocol | In Vitro | TBK1/IKKε-IN-5 effectively blocks immune suppressive cytokine elaboration by CT26 cell line spheroids, without cytotoxic effects. TBK1/IKKε-IN-5 (0.001-10 µM; 24 or 96 h) promotess secretion of IL-2 and IFN-γ in purified CD4+ and CD8+ T cells and IL-2 in Jurkat human T-cell leukemia cells. |
|---|---|---|
| In Vivo | TBK1/IKKε-IN-5 (40 mg/kg; p.o.; single daily for 26 days) shows good antitumor activity and prolongs survival, as well as induces immunologic memory of CT26 cells in mice when combines with anti-PD-L1. |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.9471 mL | 9.7354 mL | 19.4708 mL | 38.9416 mL |
| 5mM | 0.3894 mL | 1.9471 mL | 3.8942 mL | 7.7883 mL |
| 10mM | 0.1947 mL | 0.9735 mL | 1.9471 mL | 3.8942 mL |
| 20mM | 0.0974 mL | 0.4868 mL | 0.9735 mL | 1.9471 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
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Volume
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Molecular Weight*
The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.