TBB (NSC 231634; Casein Kinase II Inhibitor I)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 500mg | $850 | To Be Confirmed |
| 1g | $1350 | To Be Confirmed |
| 5g | $3415 | To Be Confirmed |
: Cat #: V5155 CAS #: 17374-26-4 Purity ≥ 98%
Description: TBB (NSC 231634; Casein Kinase II Inhibitor I) is a novel, potent, cell-permeable and ATP-competitive inhibitor of protein kinase CK2 with an IC50 of 0.15 μM for rat liver CK2.
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| Molecular Weight (MW) | 434.71 |
|---|---|
| Molecular Formula | C6HBr4N3 |
| CAS No. | 17374-26-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| SMILES Code | BrC1=C(NN=N2)C2=C(Br)C(Br)=C1Br |
| Synonyms | TBB, Tetrabromobenzotriazole, NSC 231634, NSC231634, NSC-231634 |
| Protocol | In Vitro | Investigation of the inhibitory power of TBB with a panel of 33 protein kinases shows highest potency for CK2 (casein kinase 2) (human CK2: IC50=1.6 μM at 100 μM ATP). TBB also inhibits three other kinases with less potency: CDK2 (IC50=15.6 μM), phosphorylase kinase (IC50=8.7 μM) and glycogen synthase kinase 3β (GSK3β) (IC50=11.2 μM). All other kinases tested have IC50 values 50-fold greater than that for CK2. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.3004 mL | 11.5019 mL | 23.0038 mL | 46.0077 mL |
| 5mM | 0.4601 mL | 2.3004 mL | 4.6008 mL | 9.2015 mL |
| 10mM | 0.2300 mL | 1.1502 mL | 2.3004 mL | 4.6008 mL |
| 20mM | 0.1150 mL | 0.5751 mL | 1.1502 mL | 2.3004 mL |
The molarity calculator equation
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The dilution calculator equation
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.