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| Size | Price | Stock |
|---|---|---|
| 5mg | $250 | 3-6 Days |
| 10mg | $450 | 3-6 Days |
| 25mg | $650 | 3-6 Days |
| 50mg | $1150 | 3-6 Days |
: Cat #: V15781 CAS #: 1678515-13-3 Purity ≥ 98%
Description: TASIN-1 Hydrochloride (Truncated APC Selective INhibitor-1) is a nove, potent and selective small molecule inhibitor of mutant adenomatous polyposis coli (APC). It acts by selectively killing colorectal cancer cells that express truncated APC by reducing cellular cholesterol levels and inducing apoptotic cell death through the ER stress/ROS/JNK signaling in colon cancer cells. In two authentic human CRC cell lines HCT116 (WT APC) and DLD1 (truncated APC1417), TASIN-1 exhibited potent and selective toxicity toward DLD1 cells with IC50 value of 70 nM but not toward HCT116 cells (IC50 >50 μM). TASIN-1 also reduced the endogenous cholesterol biosynthesis rate. TASIN-1 exerted its killing effects primarily by depleting cholesterol through inhibition of emopamil-binding protein (EBP) activity. However, knockdown of truncated APC (>90%) expression desensitized DLD1 cells to TASIN-1, suggesting that APC is required for TASIN-1’s cytotoxicity.
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| Molecular Formula | C18H29ClN2O3S |
|---|---|
| CAS No. | 1678515-13-3 |
| SMILES Code | CC1CCN(C2CCN(S(=O)(C3=CC=C(OC)C=C3)=O)CC2)CC1.[H]Cl |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.