Tariquidar (XR9576)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | To Be Confirmed |
| 500mg | $1230 | To Be Confirmed |
| 1g | $1845 | To Be Confirmed |
: Cat #: V1295 CAS #: 206873-63-4 Purity ≥ 98%
Description: Tariquidar (formerly XR9576; D06008; XR-9576; D-06008) is a potent and selective noncompetitive inhibitor of P-glycoprotein (P-gp) with potential antineoplastic activity.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 646.73 |
|---|---|
| Molecular Formula | C38H38N4O6 |
| CAS No. | 206873-63-4 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 52 mg/mL (80.4 mM)r |
| Water:<1 mg/mLr | |
| Ethanol:<1 mg/mL | |
| Solubility In Vivo | 30% propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL |
| Synonyms | XR9576; D06008; XR 9576; D 06008; XR-9576; D-06008 |
| Protocol | In Vitro | Tariquidar (XR9576) enhances cytotoxicity of a variety of drugs, including doxorubicin, paclitaxel, etoposide, and vincristine; In the presence of 25 -80 nM XR9576, a complete reversal of resistance can be achieved. Tariquidar is [3H]Azidopine potent inhibitor of photoaffinity labeling of P-gp, shown to be associated with proteins |
|---|---|---|
| In Vivo | In mice carrying intrinsically resistant MC26 colon tumors, the combination of Tariquidar (XR9576) enhanced the antitumor activity of doxorubicin without significantly increasing toxicity; Maximum potentiation is observed with intravenous or oral administration of 2.5 to 4.0 mg/kg. In addition, co-administration with Tariquidar (6-12 mg/kg po) completely restored the antitumor activity of paclitaxel, etoposide, and vincristine against xenografts (2780AD, H69/LX4) in nude mice of two highly resistant MDRs. Tariquidar also significantly enhances the antitumor activity of doxorubicin against MC26 tumors (injected subcutaneously in vivo) |
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 1.5462 mL | 7.7312 mL | 15.4624 mL | 30.9248 mL |
| 5mM | 0.3092 mL | 1.5462 mL | 3.0925 mL | 6.1850 mL |
| 10mM | 0.1546 mL | 0.7731 mL | 1.5462 mL | 3.0925 mL |
| 20mM | 0.0773 mL | 0.3866 mL | 0.7731 mL | 1.5462 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.