Home > Signaling Pathways>Neuronal Signaling>Notch>Tangeretin (Tangeritin; NSC53909)
Tangeretin (Tangeritin; NSC53909)

This product is for research use only, not for human use. We do not sell to patients.

Tangeretin (Tangeritin; NSC53909)
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$925Check With Us
500mg$1550Check With Us
1g$2325Check With Us
email: [email protected]        [email protected]

Cat #: V2423 CAS #: 481-53-8 Purity ≥ 98%

Description: Tangeretin (also called Tangeritin; NSC53909; NSC618905), a naturally occuring flavonoid from citrus fruit peels, has been proven to play an important role in anti-inflammatory responses and neuroprotective effects in several disease models, and was also selected as a Notch-1 inhibitor.

References: Zhang X, et al. Tangeretin enhances radiosensitivity and inhibits the radiation-induced epithelial-mesenchymal transition of gastric cancer cells. Oncol Rep. 2015 Jul;34(1):302-10.

Top Publications Citing Invivochem Products
Product Catalog 2022
Bulletin Board
Guide to Product Handling
Publications Citing InvivoChem Products
Product Promise
Promise
Molecular Weight (MW)372.37
Molecular FormulaC20H20O7
CAS No.481-53-8
Storage-20℃ for 3 years in powder formrr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 8 mg/mL (21.5 mM)rr
Water: <1 mg/mLrr
Ethanol: <1 mg/mL
SMILES CodeO=C1C=C(C2=CC=C(OC)C=C2)OC3=C(OC)C(OC)=C(OC)C(OC)=C13
SynonymsTangeritin; NSC-53909; NSC-618905; NSC 53909; NSC 618905; NSC53909; NSC618905
ProtocolIn VitroMTT and colony formation assays showed that Tangeretin enhanced the radiosensitivity of GC cells. Tangeretin also attenuated radiation-induced invasion and migration of EMT and GC cells, while reducing the expression of Notch-1, Jagged1/2, Hey-1, and Hes-1. Tangeretin triggered the upregulation of miR-410, a tumor suppressor microRNA. In addition, reexpression of miR-410 prevents radiation-induced EMT and cellular invasion
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.6855 mL13.4275 mL26.8550 mL53.7100 mL
5mM0.5371 mL2.6855 mL5.3710 mL10.7420 mL
10mM0.2686 mL1.3428 mL2.6855 mL5.3710 mL
20mM0.1343 mL0.6714 mL1.3428 mL2.6855 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
=
Concentration
 
×
Volume
 
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
×
 
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.