TAK-285

This product is for research use only, not for human use. We do not sell to patients.

TAK-285
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
250mg$980Check With Us
500mg$1520Check With Us
1g$2280Check With Us

Cat #: V0555 CAS #: 871026-44-7 Purity ≥ 98%

Description: TAK-285 (TAK285), currently being investigated by Takeda company, is a dual HER2/EGFR(HER1) inhibitor with potential antitumor activity.

References: Ishikawa T, et al. Design and synthesis of novel human epidermal growth factor receptor 2 (HER2)/epidermal growth factor receptor (EGFR) dual inhibitors bearing a pyrrolo[3,2-d]pyrimidine scaffold. J Med Chem. 2011 Dec 8;54(23):8030-50.

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Product Promise

Promise
Molecular Weight (MW)547.96
Molecular FormulaC26H25ClF3N5O3
CAS No.871026-44-7
Storage-20℃ for 3 years in powder formr
-80℃ for 2 years in solvent
Solubility In VitroDMSO: 110 mg/mL (200.7 mM)r
Water: <1 mg/mLr
Ethanol: 54 mg/mL (98.5 mM)
SMILES CodeCOC1=CC2=NC=NC(NC3=CC=CC(Cl)=C3)=C2C=C1OC
SynonymsTAK 285, TAK-285, TAK285
ProtocolIn VitroTAK-285 (Compound 34e) shows significant growth inhibitory activity against BT-474 cells (HER2-overexpressing human breast cancer cell line) with GI50 of 17 nM.
In VivoTAK-285 (Compound 34e; 50-100 mg/kg; oral administration; twice daily; for 14 days; female BALB/cAJcl mice) treatment exhibits dose-dependent tumor growth inhibition (tumor/control ratio [T/C]): 44% and 11% at 50 and 100 mg/kg, respectively) without significant body weight loss in mice.
These protocols are for reference only. InvivoChem does not independently validate these methods.
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM1.8250 mL9.1248 mL18.2495 mL36.4990 mL
5mM0.3650 mL1.8250 mL3.6499 mL7.2998 mL
10mM0.1825 mL0.9125 mL1.8250 mL3.6499 mL
20mM0.0912 mL0.4562 mL0.9125 mL1.8250 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O

Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.