T807 (AV1451)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $1150 | To Be Comfirmed |
| 500mg | $1750 | To Be Comfirmed |
| 1g | $2625 | To Be Comfirmed |
: Cat #: V32942 CAS #: 1415379-56-4 Purity ≥ 99%
Description: T-807 (AV-1451) is a novel and selective positron emission tomography (PET) for paired helical filaments of tau protein.
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| Molecular Weight (MW) | 263.2754 |
|---|---|
| Molecular Formula | C₁₆H₁₀FN₃ |
| CAS No. | 1415379-56-4 |
| SMILES Code | FC1=CC=C(C2=CC3=C(C=C2)C(C=NC=C4)=C4N3)C=N1. |
| Protocol | In Vivo | [18F]T807 is able to cross the blood–brain barrier and ished out quickly in mice model. [18F]T807 clears rapidly from the brain, with activity values decreasing from 4.43% ID/g at 5 minutes to 0.62% ID/g at 30 minutes. Kidney elimination is a significant clearance pathway, resulting in a maximum tracer concentration of 14.99% ID/g in the kidneys at 5 minutes, which decreases to 5.52% ID/g at 30 minutes. The accumulation of activity in muscle and bone remain relatively low throughout the PET scan |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.7983 mL | 18.9915 mL | 37.9830 mL | 75.9661 mL |
| 5mM | 0.7597 mL | 3.7983 mL | 7.5966 mL | 15.1932 mL |
| 10mM | 0.3798 mL | 1.8992 mL | 3.7983 mL | 7.5966 mL |
| 20mM | 0.1899 mL | 0.9496 mL | 1.8992 mL | 3.7983 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
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Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
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Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.