Synta66
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 100mg | $750 | In Stock |
| 250mg | $1400 | In Stock |
| 500mg | $2100 | In Stock |
: Cat #: V29155 CAS #: 835904-51-3 Purity ≥ 98%
Description: Synta66 is a novel and potent inhibitor/blocker of Ca2+ entry via store-operated Ca2+ release-activated Ca2+ (CRAC) channels.
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- Related Biological Data
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| Molecular Weight (MW) | 352.36 |
|---|---|
| Molecular Formula | C₂₀H₁₇FN₂O₃ |
| CAS No. | 835904-51-3 |
| Synonyms | Synta66; Synta-66; Synta 66; GSK1349571A; GSK-1349571A; GSK 1349571A;N-(2',5'-Dimethoxy[1,1'-biphenyl]-4-yl)-3-fluoro-4-pyridinecarboxamide |
| Protocol | In Vitro | Synta66 is an inhibitor of Orai, which forms the pore of the CRAC channel. Synta66 (10 μM) attenuates peak SOCE in Müller glia. Synta66 (10 μM) prevents orai channels mediating the residual SOC current in Trpc1−/− Müller cells. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8380 mL | 14.1900 mL | 28.3801 mL | 56.7601 mL |
| 5mM | 0.5676 mL | 2.8380 mL | 5.6760 mL | 11.3520 mL |
| 10mM | 0.2838 mL | 1.4190 mL | 2.8380 mL | 5.6760 mL |
| 20mM | 0.1419 mL | 0.7095 mL | 1.4190 mL | 2.8380 mL |
The molarity calculator equation
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The dilution calculator equation
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Volume(start)
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This equation is commonly abbreviated as: C1 V1 = C2 V2
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Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.