Sultamicillin tosylate

This product is for research use only, not for human use. We do not sell to patients.

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Size	Price	Stock
500mg	$450	Check With Us
1g	$750	Check With Us
5g	$1895	Check With Us

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Cat #: V3711 CAS #: 83105-70-8 Purity ≥ 98%

Description: Sultamicillin Tosylate, the tosylate salt form of Sultamicillin which is a double ester of sulbactam and ampicillin. Sultamicillin (formerly known as CP-49952 and VD 1827) is an orally available, mutual prodrug form of ampicillin and sulbactam. As an antibiotic combination (co-drug or mutual prodrug) of ampicillin/sulbactam, it contains esterified ampicillin and sulbactam and is marketed under a number of trade names, e. g. Unasyn from Pfizer. Ampicillin is a semi-synthetic orally active broad spectrum antibiotic which is linked via a methylene group with a beta-lactamase inhibitor. Sultamicillin is chemically oxymethyl penicillinate sulfone ester of ampicillin. After absorption, sultamicillin releases ampicillin and sulbactam into the system, so all the antibacterial efficacy of sultamicillin is due to ampicillin and sulbactam. Ampicillin exerts antibacterial activity against sensitive organisms by inhibiting biosynthesis of cell wall mucopeptide where as sulbactam irreversibly inhibits most important beta-lactamases that occur in resistant strains.

References: Friedel HA, et al. Sultamicillin. A review of its antibacterial activity, pharmacokinetic properties and therapeutic use. Drugs. 1989 Apr;37(4):491-522.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	766.86
Molecular Formula	C32H38N4O12S3
CAS No.	83105-70-8
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: ~100 mg/mL (130 mM)r
	Water: 10 mg/mL (12 mM)r
	Ethanol: ~100 mg/mL (130 mM)
SMILES Code	O=S(C1=CC=C(C)C=C1)(O)=O.O=C([C@@H](C(C)(C)S([C@]2([H])C3)(=O)=O)N2C3=O)OCOC([C@@H](C(C)(C)S[C@]4([H])[C@@H]5NC([C@H](N)C6=CC=CC=C6)=O)N4C5=O)=O.[H]O[H].[H]O[H]
Synonyms	VD 1827 tosylate; CP-49,952 tosylate; CP-49952; CP 49952; CP 49,952; CP49,952; CP49952 tosylate.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	1.3040 mL	6.5201 mL	13.0402 mL	26.0804 mL
5mM	0.2608 mL	1.3040 mL	2.6080 mL	5.2161 mL
10mM	0.1304 mL	0.6520 mL	1.3040 mL	2.6080 mL
20mM	0.0652 mL	0.3260 mL	0.6520 mL	1.3040 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.