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| Size | Price | Stock |
|---|---|---|
| 10mg | $100 | 3-6 Days |
| 25mg | $170 | 3-6 Days |
| 50mg | $250 | 3-6 Days |
| 100mg | $380 | 3-6 Days |
| 250mg | $650 | 3-6 Days |
| 500mg | $960 | 3-6 Days |
: Cat #: V15401 CAS #: 1055412-47-9 Purity ≥ 99%
Description: 5-chloro-SU5614 is a potent and selective FLT3 inhibitor. In Ba/F3 and AML cell lines that express constitutively activated FLT3, 5-chloro-SU5614 selectively induces growth arrest, apoptosis, and cell cycle arrest. It also exhibits inhibitory activity for FLT3. In FL-dependent cells, 5-chloro-SU5614 reverses the antiapoptotic and pro-proliferative effects of FLT3 ligand (FL). In addition to its downstream targets, the hyperphosphorylated FLT3 receptor, 5-chloro-SU5614also down-regulated the activity of mitogen-activated protein kinase (MAPK), signal transducer and activator of (STAT) 3, STAT5, and the STAT5 target genes BCL-X(L) and p21.
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| Molecular Weight (MW) | 272.73 |
|---|---|
| Molecular Formula | C15H13ClN2O |
| CAS No. | 1055412-47-9 |
| Storage | Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Synonyms | SU5614; SU 5614; SU5614. |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 3.6666 mL | 18.3332 mL | 36.6663 mL | 73.3326 mL |
| 5mM | 0.7333 mL | 3.6666 mL | 7.3333 mL | 14.6665 mL |
| 10mM | 0.3667 mL | 1.8333 mL | 3.6666 mL | 7.3333 mL |
| 20mM | 0.1833 mL | 0.9167 mL | 1.8333 mL | 3.6666 mL |
This equation is commonly abbreviated as: C1 V1 = C2 V2
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.