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STM2457

This product is for research use only, not for human use. We do not sell to patients.

STM2457
For small sizes, please check our retail website as below: www.invivochem.com
Size Price Stock
100mg$1150Check With Us
250mg$1950Check With Us
500mg$2925Check With Us
email: [email protected]        [email protected]

Cat #: V2456 CAS #: 2499663-01-1 Purity ≥ 98%

Description: STM-2457 (STM2457; STM 2457) is a novel, first-in-class, orally bioactive and selective catalytic inhibitor of METTL3 (IC50 =16.9 nM) with potential antineoplastic activity.

References: Wesley Peter Blackaby, et al. Mettl3 inhibitory compounds. WO2020201773A1.

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Molecular Weight (MW)444.53
Molecular FormulaC25H28N6O2
CAS No.2499663-01-1
SMILES CodeC1=CC=CC2=NC(C(=O)NCC3N=C4C=CC(CNCC5CCCCC5)=CN4C=3)=CC(=O)N12
SynonymsSTM2457; STM-2457; STM 2457;
Preparing Stock Solutions
Solvent volume to be added Mass (the weight of a compound)
Mother liquor concentration 1mg5mg10mg20mg
1mM2.2496 mL11.2478 mL22.4957 mL44.9913 mL
5mM0.4499 mL2.2496 mL4.4991 mL8.9983 mL
10mM0.2250 mL1.1248 mL2.2496 mL4.4991 mL
20mM0.1125 mL0.5624 mL1.1248 mL2.2496 mL
Quality Control Documentation
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
 
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Concentration
 
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Volume
 
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Molecular Weight*
The dilution calculator equation
Concentration(start) × Volume(start) = Concentration(final) × Volume(final)

This equation is commonly abbreviated as: C1 V1 = C2 V2

Concentration(start)
C1
 
×
 
Volume(start)
V1
 
=
 
Concentration(final)
C2
 
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Volume(final)
V2
Step One: Enter information below
Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals
Step Two: Enter the in vivo formulation
%DMSO + % + %Tween 80 + %ddH2O
Calculation Results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH2O,mix and clarify.
Note:
  • (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
  • (2) Be sure to add the solvent(s) in order.