Stavudine (d4T)

This product is for research use only, not for human use. We do not sell to patients.

For small sizes, please check our retail website as below: www.invivochem.com

Size	Price	Stock
5g	$330	Check With Us
10g	$530	Check With Us
20g	$795	Check With Us

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Cat #: V1825 CAS #: 3056-17-5 Purity ≥ 98%

Description: Stavudine (also known as BMY-27857, Sanilvudine, NSC 163661, and d4T) is a potent antiretroviral medication of the nucleoside analog reverse transcriptase inhibitor (NARTI) class, it is active against HIV and has been approved for preventing and treating HIV/AIDS.

References: La Rosa F, et al. Stavudine Reduces NLRP3 Inflammasome Activation and Modulates Amyloid-β Autophagy. J Alzheimers Dis. 2019;72(2):401-412.

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Physicochemical and Storage Information
Protocol
Related Biological Data
Stock Solution Preparation
Quality Control Documentation

Molecular Weight (MW)	224.21
Molecular Formula	C10H12N2O4
CAS No.	3056-17-5
Storage	-20℃ for 3 years in powder formr
Storage	-80℃ for 2 years in solvent
Solubility In Vitro	DMSO: 45 mg/mL (200.7 mM)r
	Water: <1 mg/mLr
	Ethanol: 15 mg/mL (66.9 mM)
Solubility In Vivo	0.5% CMC Na: 30mg/mL
Synonyms	d4T; BMY-27857, BMY27857, BMY27857, Sanilvudine, NSC 163661; NSC-163661; NSC163661; Stavudine; Stavudinum; Zerit

Protocol	In Vitro	Stavudine (d4T) (50 μM) significantly reduces the expression of the NLRP3 inflammasome gene, IL-18 production and Aβ 42-stimulated cellular production of IL-1β in THP-1 derived macrophages

These protocols are for reference only. InvivoChem does not independently validate these methods.

Preparing Stock Solutions

Solvent volume to be added	Mass (the weight of a compound)
Mother liquor concentration	1mg	5mg	10mg	20mg
1mM	4.4601 mL	22.3005 mL	44.6010 mL	89.2021 mL
5mM	0.8920 mL	4.4601 mL	8.9202 mL	17.8404 mL
10mM	0.4460 mL	2.2301 mL	4.4601 mL	8.9202 mL
20mM	0.2230 mL	1.1150 mL	2.2301 mL	4.4601 mL

Quality Control Documentation	Select Batch Purity ≥ 98% COA MSDS NMR HPLC

The molarity calculator equation

Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)

Mass

Concentration

Volume

Molecular Weight*

The dilution calculator equation

Concentration_(start) × Volume_(start) = Concentration_(final) × Volume_(final)

This equation is commonly abbreviated as: C₁ V₁ = C₂ V₂

Concentration_(start)

Volume_(start)

Concentration_(final)

Volume_(final)

Step One: Enter information below

Dosage mg/kg Average weight of animals g Dosing volume per animal µL Number of animals

Step Two: Enter the in vivo formulation

%DMSO + % + %Tween 80 + %ddH₂O

Calculation Results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in µL DMSO(Master liquid concentration mg/mL) ,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation: Take µL DMSO master liquid, next add µL PEG300, mix and clarify, next add µL Tween 80,mix and clarify, next add µL ddH₂O,mix and clarify.

Note:

(1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
(2) Be sure to add the solvent(s) in order.