(S,R,S)-AHPC hydrochloride
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $420 | Check With Us |
| 500mg | $600 | Check With Us |
| 1g | $900 | Check With Us |
: Cat #: V4063 CAS #: 1448189-80-7 Purity ≥ 98%
Description: Protein degrader 1 HCl (hydrochloride) or PROTAC-VHL-ligand is a novel and potent small molecule ligand for VHL (Von Hippel-Lindau), which is an E3 ligase which has been targeted in many PROTAC (proteolysis-targeting chimeras) degraders.
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| Molecular Weight (MW) | 467.02 |
|---|---|
| Molecular Formula | C₂₂H₃₁ClN₄O₃S |
| CAS No. | 1448189-80-7 |
| Storage | -20℃ for 3 years in powder formr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: > 10 mMr |
| Water: > 50 mg/mLr | |
| Ethanol: N/A | |
| SMILES Code | O=C([C@H](C[C@@H](O)C1)N1C([C@@H](N)C(C)(C)C)=O)NCC2=CC=C(C(SC=N3)=C3C)C=C2.Cl |
| Synonyms | Protein degrader 1 hydrochloride; Protein degrader 1 TFA;VH032-NH2 TFA; VHL ligand 1 TFA; Protein degrader 1 TFA , VHL-7526 TFA; VHL-7526; VHL7526; VHL 7526 |
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.1412 mL | 10.7062 mL | 21.4124 mL | 42.8247 mL |
| 5mM | 0.4282 mL | 2.1412 mL | 4.2825 mL | 8.5649 mL |
| 10mM | 0.2141 mL | 1.0706 mL | 2.1412 mL | 4.2825 mL |
| 20mM | 0.1071 mL | 0.5353 mL | 1.0706 mL | 2.1412 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
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Concentration
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Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.