SRPIN340 (SRPK inhibitor)
This product is for research use only, not for human use. We do not sell to patients.
For small sizes, please check our retail website as below: www.invivochem.com
| Size | Price | Stock |
|---|---|---|
| 250mg | $750 | Check With Us |
| 500mg | $1450 | Check With Us |
| 1g | $2175 | Check With Us |
: Cat #: V1957 CAS #: 218156-96-8 Purity ≥ 98%
Description: SRPIN340 is a potent, selective and ATP-competitive SRPK (serine-arginine-rich protein kinase) inhibitor with Ki of 0.89 μM for SRPK1, it exhibited no significant inhibitory activity against more than 140 other kinases.
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- Physicochemical and Storage Information
- Protocol
- Related Biological Data
- Stock Solution Preparation
- Quality Control Documentation
| Molecular Weight (MW) | 349.35 |
|---|---|
| Molecular Formula | C18H18F3N3O |
| CAS No. | 218156-96-8 |
| Storage | -20℃ for 3 years in powder formrrrrrr |
| -80℃ for 2 years in solvent | |
| Solubility In Vitro | DMSO: 70 mg/mL (200.4 mM)rrrrrr |
| Water: <1 mg/mLrrrrrr | |
| Ethanol: 70 mg/mL (200.4 mM) | |
| Solubility In Vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80: 8 mg/mL |
| Protocol | In Vitro | SRPIN340 is a serine arginine-rich protein kinase (SRPK) inhibitor against the K of SRPK1i is 0.89 μM. SRPIN340 also inhibits SRPK2, but has no significant inhibitory effect on other SRPKs such as Clk1 and Clk4. SRPIN340 promotes the degradation of SRp75, which is required for HIV expression. SRPIN340 inhibits the Sindbis virus (IC50, 60 μM) and transmission of SARS virus. |
|---|
These protocols are for reference only. InvivoChem does not
independently validate these methods.
| Solvent volume to be added | Mass (the weight of a compound) | |||
|---|---|---|---|---|
| Mother liquor concentration | 1mg | 5mg | 10mg | 20mg |
| 1mM | 2.8625 mL | 14.3123 mL | 28.6246 mL | 57.2492 mL |
| 5mM | 0.5725 mL | 2.8625 mL | 5.7249 mL | 11.4498 mL |
| 10mM | 0.2862 mL | 1.4312 mL | 2.8625 mL | 5.7249 mL |
| 20mM | 0.1431 mL | 0.7156 mL | 1.4312 mL | 2.8625 mL |
The molarity calculator equation
Mass(g) = Concentration(mol/L) × Volume(L) × Molecular Weight(g/mol)
Mass
=
Concentration
×
Volume
×
Molecular Weight*
The dilution calculator equation
Concentration(start)
×
Volume(start)
=
Concentration(final)
×
Volume(final)
This equation is commonly abbreviated as: C1 V1 = C2 V2
Concentration(start)
C1
×
Volume(start)
V1
=
Concentration(final)
C2
×
Volume(final)
V2
Step One: Enter information below
Dosage mg/kg
Average weight of animals g
Dosing volume per animal µL
Number of animals
Step Two: Enter the in vivo formulation
%DMSO
+
%
+
%Tween 80
+
%ddH2O
Calculation Results:
Working concentration:
mg/ml;
Method for preparing DMSO master liquid:
mg
drug pre-dissolved in
µL
DMSO(Master liquid concentration
mg/mL)
,Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.
Method for preparing in vivo formulation:
Take
µL
DMSO master liquid, next add
µL
PEG300, mix and clarify, next add
µL
Tween 80,mix and clarify, next add
µL
ddH2O,mix and clarify.
Note:
- (1) Please be sure that the solution is clear before the addition of next solvent. Dissolution methods like vortex, ultrasound or warming and heat may be used to aid dissolving.
- (2) Be sure to add the solvent(s) in order.